diff --git a/server/client.go b/server/client.go
index 07bb929d..6d1728a1 100644
--- a/server/client.go
+++ b/server/client.go
@@ -173,6 +173,7 @@ const (
 	Revocation
 	InternalClient
 	MsgHeaderViolation
+	NoRespondersRequiresHeaders
 	ClusterNameConflict
 )
 
@@ -420,23 +421,24 @@ func (s *subscription) isClosed() bool {
 }
 
 type clientOpts struct {
-	Echo        bool   `json:"echo"`
-	Verbose     bool   `json:"verbose"`
-	Pedantic    bool   `json:"pedantic"`
-	TLSRequired bool   `json:"tls_required"`
-	Nkey        string `json:"nkey,omitempty"`
-	JWT         string `json:"jwt,omitempty"`
-	Sig         string `json:"sig,omitempty"`
-	Token       string `json:"auth_token,omitempty"`
-	Username    string `json:"user,omitempty"`
-	Password    string `json:"pass,omitempty"`
-	Name        string `json:"name"`
-	Lang        string `json:"lang"`
-	Version     string `json:"version"`
-	Protocol    int    `json:"protocol"`
-	Account     string `json:"account,omitempty"`
-	AccountNew  bool   `json:"new_account,omitempty"`
-	Headers     bool   `json:"headers,omitempty"`
+	Echo         bool   `json:"echo"`
+	Verbose      bool   `json:"verbose"`
+	Pedantic     bool   `json:"pedantic"`
+	TLSRequired  bool   `json:"tls_required"`
+	Nkey         string `json:"nkey,omitempty"`
+	JWT          string `json:"jwt,omitempty"`
+	Sig          string `json:"sig,omitempty"`
+	Token        string `json:"auth_token,omitempty"`
+	Username     string `json:"user,omitempty"`
+	Password     string `json:"pass,omitempty"`
+	Name         string `json:"name"`
+	Lang         string `json:"lang"`
+	Version      string `json:"version"`
+	Protocol     int    `json:"protocol"`
+	Account      string `json:"account,omitempty"`
+	AccountNew   bool   `json:"new_account,omitempty"`
+	Headers      bool   `json:"headers,omitempty"`
+	NoResponders bool   `json:"no_responders,omitempty"`
 
 	// Routes only
 	Import *SubjectPermission `json:"import,omitempty"`
@@ -1564,6 +1566,17 @@ func (c *client) processConnect(arg []byte) error {
 			c.closeConnection(BadClientProtocolVersion)
 			return ErrBadClientProtocol
 		}
+		// Check to see that if no_responders is requested
+		// they have header support on as well.
+		c.mu.Lock()
+		misMatch := c.opts.NoResponders && !c.headers
+		c.mu.Unlock()
+		if misMatch {
+			c.sendErr(ErrNoRespondersRequiresHeaders.Error())
+			c.closeConnection(NoRespondersRequiresHeaders)
+			return ErrNoRespondersRequiresHeaders
+
+		}
 		if verbose {
 			c.sendOK()
 		}
@@ -3165,9 +3178,33 @@ func (c *client) processInboundClientMsg(msg []byte) bool {
 		didDeliver = c.sendMsgToGateways(c.acc, msg, c.pa.subject, c.pa.reply, qnames) || didDeliver
 	}
 
+	// Check to see if we did not deliver to anyone and the client has a reply subject set
+	// and wants notification of no_responders.
+	if !didDeliver && len(c.pa.reply) > 0 {
+		c.mu.Lock()
+		if c.opts.NoResponders {
+			if sub := c.subForReply(c.pa.reply); sub != nil {
+				proto := fmt.Sprintf("HMSG %s %s 16 16\r\nNATS/1.0 503\r\n\r\n", c.pa.reply, sub.sid)
+				c.queueOutbound([]byte(proto))
+			}
+		}
+		c.mu.Unlock()
+	}
+
 	return didDeliver
 }
 
+// Return the subscription for this reply subject. Only look at normal subs for this client.
+func (c *client) subForReply(reply []byte) *subscription {
+	r := c.acc.sl.Match(string(reply))
+	for _, sub := range r.psubs {
+		if sub.client == c {
+			return sub
+		}
+	}
+	return nil
+}
+
 // This is invoked knowing that this client has some GW replies
 // in its map. It will check if one is find for the c.pa.subject
 // and if so will process it directly (send to GWs and LEAFs) and
diff --git a/server/client_test.go b/server/client_test.go
index 48294251..c1b20f6b 100644
--- a/server/client_test.go
+++ b/server/client_test.go
@@ -194,6 +194,36 @@ func TestClientCreateAndInfo(t *testing.T) {
 	}
 }
 
+func TestClientNoResponderSupport(t *testing.T) {
+	opts := defaultServerOptions
+	opts.Port = -1
+	s := New(&opts)
+
+	c, _, _ := newClientForServer(s)
+	defer c.close()
+
+	// Force header support if you want to do no_responders. Make sure headers are set.
+	if err := c.parse([]byte("CONNECT {\"no_responders\":true}\r\n")); err == nil {
+		t.Fatalf("Expected error")
+	}
+
+	c, cr, _ := newClientForServer(s)
+	defer c.close()
+
+	c.parseAsync("CONNECT {\"headers\":true, \"no_responders\":true}\r\nSUB reply 1\r\nPUB foo reply 2\r\nok\r\n")
+
+	l, err := cr.ReadString('\n')
+	if err != nil {
+		t.Fatalf("Error receiving msg from server: %v\n", err)
+	}
+
+	am := hmsgPat.FindAllStringSubmatch(l, -1)
+	if len(am) == 0 {
+		t.Fatalf("Did not get a match for %q", l)
+	}
+	checkPayload(cr, []byte("NATS/1.0 503\r\n\r\n"), t)
+}
+
 func TestServerHeaderSupport(t *testing.T) {
 	opts := defaultServerOptions
 	opts.Port = -1
diff --git a/server/errors.go b/server/errors.go
index f9d46777..e323ce06 100644
--- a/server/errors.go
+++ b/server/errors.go
@@ -145,6 +145,10 @@ var (
 	// but they are not supported on this server.
 	ErrMsgHeadersNotSupported = errors.New("message headers not supported")
 
+	// ErrNoRespondersRequiresHeaders signals that a client needs to have headers
+	// on if they want no responders behavior.
+	ErrNoRespondersRequiresHeaders = errors.New("no responders requires headers support")
+
 	// ErrClusterNameConfigConflict signals that the options for cluster name in cluster and gateway are in conflict.
 	ErrClusterNameConfigConflict = errors.New("cluster name conflicts between cluster and gateway definitions")